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Antifungal Drugs

Azole: a broad spectrum antifungal developed in 1967. It was one of the first azoles to be developed. Formulations are now generic in a number of countries. It is effective against Candida albicans and the dermatophytes. Its action is fungistatic or fungicidal, depending upon the concentration used. This azole drug is available in a variety of dosage forms...     Details.

Antifungal, topical. Ciclopirox olamine is a hydroxypyridone antifungal that is structurally unrelated to other antifungal agents. It was first introduced in 1975 and has been accepted and used in Europe for many years. It was approved by the FDA in 1982 for the treatment of superficial fungal infections.     Details.

Ketoconazole is an azole medication used to treat a broad spectrum of fungi It was originally developed in the late 1970's in the oral form and granted FDA acceptance in 1981. Shortly after the topical formulations were undergoing trials and proven effective. The 2% cream and 1% shampoo are now available over the counter.     Details.

Terbinafine Hydrochloride
Antifungal, allylamine -one of the first antifungals of the allylamine class, discovered in 1974. It was approved for systemic use in the UK in 1991, and for topical use in the USA in 1992. Terbinafine is an antifungal effective against Dermatophytes, Aspergillus sp., and Candida and Pityrosporum yeasts.     Details.

Itraconazole is an antifungal azole. It is a synthetic triazole analogue with a wide spectrum of antifungal activity. It was first synthesized in 1980, and approved in Europe in 1987. It was approved by the FDA in 1992 for systemic mycoses, and then for onychomycoses in 1995, and for use by pulse therapy in 1997. In 2000, itraconazole was also approved to treat blastomycosis, histoplasmosis, and aspergellosis in patients intolerant of amphotericin B.     Details.

Fluconazole is an antifungal azole. It is a broad spectrum antifungal, first approved in Europe in 1988 and then in America in 1990. It was the first single dose treatment approved for vaginal candidiasis. Fluconazole is an effective agent in the treatment and prophylaxis of Candidal infection.     Details.



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